Amphlett revealed that she was battling breast cancer in 2010, and had also been diagnosed with Multiple Sclerosis. Because of her MS, Amphlett was unable to undergo radiation treatment for her cancer. At the time of her diagnosis she told Fairfax Newspapers, "I'll get over it - I've got songs to sing, I've got stages to perform on. I'm a keep-on-going sort of girl."

The Divinyls had four Top 10 albums in Australia and one in the U.S. Although they recorded several classics with producer Mike Chapman, they were perhaps best known internationally for “I Touch Myself,” which was a #1 hit in Australia and reached the Top 10 in the U.K. and U.S. in 1991.

Just last month Amphlett was named among the Top Ten Australian singers of all time by Australia's The Age newspaper.

Chrissy's husband, Divinyls drummer Charlie Drayton, issued this statement:

"Our beloved Chrissy peacefully passed this afternoon.

Christine Joy Amphlett succumbed to the effects of breast cancer and multiple sclerosis, diseases she vigorously fought with exceptional bravery and dignity. She passed gently, in her sleep, surrounded by close friends and family, including husband of fourteen years, musician Charley Drayton; her sister, Leigh; nephew, Matt; and cousin Patricia Amphlett (“Little Pattie”).

Chrissy’s light burns so very brightly. Hers was a life of passion and creativity; she always lived it to the fullest. With her force of character and vocal strength she paved the way for strong, sexy, outspoken women.

Best remembered as the lead singer of the ARIA Hall of Fame inductee, Divinyls; last month she was named one of Australia’s top ten singers of all time. Chrissy expressed hope that her worldwide hit “I Touch Myself” would be utilized to remind all women to perform annual breast examinations.

Chrissy was a true pioneer and a treasure to all whose lives her music and spirit touched."